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Anatomical specificity of functional amygdala imaging of responses to stimuli with positive and negative emotional valence

Ball, Tonio and Derix, Johanna and Wentlandt, Johanna and Wieckhorst, Birgit and Speck, Oliver and Schulze-Bonhage, Andreas and Mutschler, Isabella. (2009) Anatomical specificity of functional amygdala imaging of responses to stimuli with positive and negative emotional valence. Journal of neuroscience methods, 180 (1). pp. 57-70.

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Official URL: http://edoc.unibas.ch/dok/A5842010

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Abstract

Non-invasive neuroimaging is increasingly used for investigating the human amygdala. Accurate functional localization in the amygdala region is, however, challenging and quantitative data on the anatomical specificity of functional amygdala imaging is lacking. We have therefore retrospectively investigated 114 recently published human functional imaging studies concerned with the amygdala. We determined the anatomical assignment probabilities of a total of 339 reported activation sites to the amygdala defined using a cytoarchitectonically verified probabilistic atlas system. We find that approximately 50% of reported responses were located in the region with high probability (< or =80%) of belonging to the amygdala. This group included responses related both to stimuli of positive and negative emotional valence. Approximately 10% of reported response sites were assigned to the hippocampus, with up to 100% assignment probability. The remaining peaks were either located in the border regions of the amygdala and/or hippocampus or outside of both of these structures. Within the amygdala, the majority of peaks (96.3%) were found in the laterobasal (LB) and superficial (SF) subregions. Only 3.7% of peaks were found in the centromedial group (CM), possibly because anatomically delineating the CM region of the amygdala is particularly difficult and hence its extent might have been underestimated. Moreover, these results show that a core region of the amygdala is responsive to stimuli both of positive and negative emotional valence. The current findings highlight the usefulness of probabilistic amygdala maps and also point to a need for the development of accurate in vivo delineation and parcellation of the amygdala.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Mutschler, Isabella
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0165-0270
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:27 Dec 2017 08:16
Deposited On:14 Sep 2012 07:16

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