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Dopamine Receptor D4 Polymorphism Predicts the Effect of L-DOPA on Gambling Behavior

Eisenegger, C. and Knoch, D. and Ebstein, RP. and Gianotti, LR. and Sándor, PS. and Fehr, E.. (2010) Dopamine Receptor D4 Polymorphism Predicts the Effect of L-DOPA on Gambling Behavior. Biological Psychiatry, Vol. 67, H. 8. pp. 702-706.

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Official URL: http://edoc.unibas.ch/dok/A5260079

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Abstract

There is ample evidence that a subgroup of Parkinson’s disease patients who are treated with dopaminergic drugs develop certain behavioral addictions such as pathological gambling. The fact that only a subgroup of these patients develops pathological gambling suggests an interaction between dopaminergic drug treatment and individual susceptibility factors. These are potentially of genetic origin, since research in healthy subjects suggests that vulnerability for pathological gambling may be linked to variation in thedopamine receptor D4 (DRD4) gene. Using a pharmacogenetic approach, we investigated how variation in this gene modulates the impact of dopaminergic stimulation on gambling behavior in healthy subjects.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Social and Affective Neuroscience (Knoch)
UniBasel Contributors:Gianotti, Lorena R. R. and Knoch, Daria
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0006-3223
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:22
Deposited On:14 Sep 2012 07:15

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