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Genome-wide linkage analysis of ADHD using high-density SNP arrays : novel loci at 5q13.1 and 14q12

Romanos, M. and Freitag, C. and Jacob, C. and Craig, D. W. and Dempfle, A. and Nguyen, T. T. and Halperin, R. and Walitza, S. and Renner, T. J. and Seitz, C. and Romanos, J. and Palmason, H. and Reif, A. and Heine, M. and Windemuth-Kieselbach, C. and Vogler, C. and Sigmund, J. and Warnke, A. and Schäfer, H. and Meyer, J. and Stephan, D. A. and Lesch, K. P.. (2008) Genome-wide linkage analysis of ADHD using high-density SNP arrays : novel loci at 5q13.1 and 14q12. Molecular psychiatry, 13 (5). pp. 522-530.

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Abstract

Previous genome-wide linkage studies applied the affected sib-pair design; one investigated extended pedigrees of a genetic isolate. Here, results of a genome-wide high-density linkage scan of attention-deficit/hyperactivity disorder (ADHD) using an array-based genotyping of approximately 50 K single nucleotide polymorphism (SNPs) markers are presented. We investigated eight extended pedigrees of German origin that were non-related, not part of a genetic isolate and ascertained on the basis of clinical referral. Two parametric analyses maximizing LOD scores (MOD) and a non-parametric analysis for both a broad and a narrow phenotype approach were conducted. Novel linkage loci across all families were detected at 2q35, 5q13.1, 6q22-23 and 14q12, within individual families at 18q11.2-12.3. Further linkage regions at 7q21.11, 9q22 and 16q24.1 in all families, and at 1q25.1, 1q25.3, 9q31.1-33.1, 9q33, 12p13.33, 15q11.2-13.3 and 16p12.3-12.2 in individual families replicate previous findings. High-resolution linkage mapping points to several novel candidate genes characterized by dense expression in the brain and potential impact on disorder-relevant synaptic transmission. Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Vogler, Christian
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1359-4184
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:19 Oct 2017 10:13
Deposited On:14 Sep 2012 07:12

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