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Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques : absolute metabolic values over 2 years during a clinical pharmacological study

Mader, I. and Roser, W. and Kappos, L. and Hagberg, G. and Seelig, J. and Radue, E. W. and Steinbrich, W.. (2000) Serial proton MR spectroscopy of contrast-enhancing multiple sclerosis plaques : absolute metabolic values over 2 years during a clinical pharmacological study. American Journal of Neuroradiology, 21 (7). pp. 1220-1227.

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Official URL: http://edoc.unibas.ch/dok/A5257411

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Abstract

BACKGROUND AND PURPOSE: The time courses of total creatine (Cr), N-acetylaspartate (NAA), choline (Cho), and myo-inositol have not previously been investigated in the follow-up of contrast-enhancing multiple sclerosis (MS) plaques. Therefore, over a period of 2 years, we compared the absolute concentrations of these metabolites between patients treated with a placebo or 15 +/- deoxyspergualin (DSG) and between clinical groups with relapsing-remitting or secondary-progressive MS. METHODS: Sixteen patients, recruited from a pharmacological study of DSG, and 11 healthy control subjects were investigated by a stimulated-echo acquisition mode sequence (TR/TE = 3000/20). The selected volume initially contained a contrast-enhancing plaque, which was followed up for a period of 2 years. RESULTS: In contrast-enhancing plaques, Cho was significantly elevated and showed a significant reduction after both 3 and 12 months. The initially normal Cr significantly increased between 3 and 12 months, and was negatively correlated with plaque volume on T1-weighted MR images. NAA initially showed normal values, a significant decrease at 1 month, and a slow recovery over 2 years. Myo-inositol did not show a clear tendency. The placebo group did not differ from the treated group, nor did the relapsing-remitting group differ from the secondary-progressive group. CONCLUSION: The contradictory time courses of Cr and NAA show that an absolute quantification in proton MR spectroscopy in MS is necessary to avoid a false interpretation of reduced NAA/Cr ratios. The increase in Cr is probably due to remyelination. The initial dip and later recovery of NAA seem to be related to diminishing edema and remyelination.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Neuroradiology
ISSN:0195-6108
e-ISSN:1936-959X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Nov 2017 15:43
Deposited On:22 Mar 2012 13:18

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