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Enantioselective Michael Addition to α,β-Unsaturated Aldehydes: Combinatorial Catalyst Preparation and Screening, Reaction Optimization, and Mechanistic Studies

Fleischer, Ivana and Pfaltz, Andreas. (2010) Enantioselective Michael Addition to α,β-Unsaturated Aldehydes: Combinatorial Catalyst Preparation and Screening, Reaction Optimization, and Mechanistic Studies. Chemistry - A European Journal, 16 (1). pp. 95-99.

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Official URL: http://edoc.unibas.ch/dok/A5841362

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Abstract

Shortcut to chiral catalysts: An efficient combinatorial strategy based on back reaction screening by ESI-MS allows rapid evaluation of organocatalysts for the asymmetric Michael addition to α,β-unsaturated aldehydes (see scheme). An unexpected nonlinear effect has been observed in this reaction, resulting from a double nucleophilic–electrophilic activation mechanism involving two catalyst molecules.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0947-6539
e-ISSN:1521-3765
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Apr 2017 13:20
Deposited On:14 Sep 2012 06:59

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