Iridium-Catalyzed Asymmetric Hydrogenation of N-Protected Indoles

Baeza, Alejandro and Pfaltz, Andreas. (2010) Iridium-Catalyzed Asymmetric Hydrogenation of N-Protected Indoles. Chemistry - A European Journal, 16 (7). pp. 2036-2039.

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Official URL: http://edoc.unibas.ch/dok/A5841364

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Chiral indolines substituted at C-2 or C-3 can be prepared in high yield and excellent enantioselectivity by asymmetric hydrogenation of N-protected indoles by using Ir catalysts with chiral N,P ligands. With less reactive substrates, the reaction had to be carried out at elevated temperature, but even at 60–110 °C very high enantiomeric excesses of up to 98–99 % could be obtained.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2017 13:18
Deposited On:14 Sep 2012 06:59

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