edoc

Chiral Pyridyl Phosphinites with Large Aryl Substituents as Efficient Ligands for the Asymmetric Iridium-Catalyzed Hydrogenation of Difficult Substrates

Woodmansee, David and Müller, Marc-André and Pfaltz, Andreas. (2010) Chiral Pyridyl Phosphinites with Large Aryl Substituents as Efficient Ligands for the Asymmetric Iridium-Catalyzed Hydrogenation of Difficult Substrates. Chemical Science, 2010 (1). pp. 72-78.

[img]
Preview
PDF - Published Version
193Kb

Official URL: http://edoc.unibas.ch/dok/A5841367

Downloads: Statistics Overview

Abstract

Using a flexible synthesis, new chiral iridium N,P complexes with sterically demanding aryl substituents were synthesized and used in the asymmetric hydrogenation of difficult substrates. Unprecedented enantioselectivities were obtained in the asymmetric hydrogenation of α-substituted α,β-unsaturated esters and dihydronaphthalenes. The variety of aryl substituents incorporated into the catalyst has made it possible to obtain useful structure selectivity relationships for important classes of substrates.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas
Item Type:Article
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:2041-6520
e-ISSN:2041-6539
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:10 Apr 2017 13:48
Deposited On:14 Sep 2012 06:59

Repository Staff Only: item control page