Towards Targeted Drug Delivery by Covalent Ligand-Modified Polymeric Nanocontainers

Egli, Stefan and Fischer, Barbara and Hartmann, Sonja and Hunziker, Patrick and Meier, Wolfgang and Rigler, Per. (2010) Towards Targeted Drug Delivery by Covalent Ligand-Modified Polymeric Nanocontainers. Macromolecular Symposia, Vol. 296. pp. 278-285.

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Official URL: http://edoc.unibas.ch/dok/A5841675

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Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self-assembly of block copolymers consisting of either Polydimethoxysiloxane-b-Polymethyloxazoline-b-Polydimethoxysiloxane (PDMS-b-PMOXA-b-PDMS) or functionalized PDMS-b-PMOXA-b-PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly-guanosin ligand, the latter by using the Huisgen 1,3-dipolar cycloaddn. The success of the covalent modification of the block copolymer has been detd. by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chem. approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1. [on SciFinder(R)]
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:19
Deposited On:14 Sep 2012 06:59

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