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Maternal psychopathology - a risk factor for affective, anxiety and substance use disorders in offspring? Results from a prospective-longitudinal community study

Schreier, A. and Wittchen, H. U. and Hoefler, M. and Lieb, R.. (2007) Maternal psychopathology - a risk factor for affective, anxiety and substance use disorders in offspring? Results from a prospective-longitudinal community study. Pharmacopsychiatry, Vol. 40, H. 5. p. 216.

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Official URL: http://edoc.unibas.ch/dok/A5838802

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Abstract

In a variety of studies it has been demonstrated that affective, anxiety and substance use disorders aggregate in families. These results often get interpreted as parental disorders being a risk factor for psychopathology in offspring. However, rarely has it been demonstrated that the parental disorder precedes that of the child, an attribute necessary for the definition of a risk factor (Kraemer et al 1997). The aim of the present study is to examine whether maternal psychopathology precedes the onset of psychopathology in offspring. Analyses are based on a cohort of 933 mother-child pairs from the EDSP study. Offspring were 14-17-years of age at baseline and were followed-up over a five years period. Diagnostic information on affective, anxiety and substance use disorders of mothers and children was based on the M-CIDI/DSM-IV. In prospective analyses it could be demonstrated that maternal anxiety disorders are associated with elevated incidence rates of affective disorders in offspring during follow-up (18.9% vs. 12.1%; OR=1.7,95% CI=1.1-2.7) and maternal substance use disorders with incident offspring anxiety (21.7% vs. 13.2%; OR=1.8,95% CI=1.1-3.1) as well as substance use disorders (36.5% vs. 28.2%; OR=1.6,95% CI=1.1-2.5). These results are important with regard to the prevention of psychopathology in children suggesting that maternal anxiety can be considered a risk factor for affective disorders and maternal substance use for anxiety and substance use disorders in offspring.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind
Item Type:Article
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Thieme
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:14 Sep 2012 07:19
Deposited On:14 Sep 2012 06:58

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