Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis : a meta-analysis

Noazin, S. and Khamesipour, A. and Moulton, L. H. and Tanner, M. and Nasseri, K. and Modabber, F. and Sharifi, I. and Khalil, E. A. and Bernal, I. D. and Antunes, C. M. and Smith, P. G.. (2009) Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis : a meta-analysis. Vaccine, 27 (35). pp. 4747-4753.

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Official URL: http://edoc.unibas.ch/dok/A5843202

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Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with 'first-generation' whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
UniBasel Contributors:Tanner, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Identification Number:
  • pmid: 19540273
  • : 10.1016/j.vaccine.2009.05.084
Last Modified:03 Nov 2017 13:00
Deposited On:14 Sep 2012 06:45

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