Mueller, Y. and Mbulamberi, D. B. and Odermatt, P. and Hoffmann, A. and Loutan, L. and Chappuis, F.. (2009) Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda. Tropical medicine and international health : TM & IH : a European journal, 14 (8). pp. 910-917.
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Official URL: http://edoc.unibas.ch/dok/A5843311
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Abstract
OBJECTIVE: To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda. METHODS: Retrospective analysis of VL patients' clinical data collected for project monitoring by Medecins Sans Frontieres in Amudat, eastern Uganda. RESULTS: Between 2000 and 2005, of 3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age 15 years, concomitant tuberculosis or hepatopathy, and drug-related adverse events. The case-fatality rate among patients <45 years of age was strikingly high (29.0%). CONCLUSION: Subgroups of VL patients at higher risk of death during treatment with drugs currently available in Uganda were identified. Less toxic drugs should be evaluated and used in these patients
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Health Impact Assessment (Utzinger) |
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| UniBasel Contributors: | Odermatt, Peter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Blackwell Science |
| ISSN: | 1360-2276 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 07 Nov 2017 09:56 |
| Deposited On: | 14 Sep 2012 06:43 |
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