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Flash chromatography on cartridges for the separation of plant extracts - Rules for the selection of chromatographic conditions and comparison with medium pressure liquid chromatography

Weber, P. and Hamburger, M. and Schafroth, N. and Potterat, O.. (2011) Flash chromatography on cartridges for the separation of plant extracts - Rules for the selection of chromatographic conditions and comparison with medium pressure liquid chromatography. Fitoterapia, Vol. 82. pp. 155-161.

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Official URL: http://edoc.unibas.ch/dok/A5839906

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Abstract

Empirical rules for the selection of chromatographic conditions on flash chromatography cartridges were developed, with an emphasis on gradient mode. These rules were then tested with separation of extracts from important medicinal plants including Curcuma xanthorrhiza, Piper nigrum and Salvia milthiorrhiza. Sepacore® cartridges enabled a good separation of compounds with a broad range of polarity, as typically found in plant extracts. The chromatographic resolution remained, however, lower than that achieved on classical columns packed with material of smaller particle size. For poorly soluble extracts, solid introduction gave better results than liquid injection.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and Potterat, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0367-326X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:40

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