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Cell division orientation in animals

Gillies, Taryn E. and Cabernard, Clemens. (2011) Cell division orientation in animals. Current biology, Vol. 21, H. 15 , R599-609.

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Official URL: http://edoc.unibas.ch/dok/A5848297

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Abstract

Cell division orientation during animal development can serve to correctly organize and shape tissues, create cellular diversity or both. The underlying cellular mechanism is regulated spindle orientation. Depending on the developmental context, extrinsic signals or intrinsic cues control the correct orientation of the mitotic spindle. Cell geometry has been known to be another determinant of spindle orientation and recent results have shed new light on the link between cellular shape and cell division orientation. The importance of controlling spindle orientation is manifested in neurodevelopmental defects such as microcephaly, tumor initiation as well as defects in tissue architecture and cell fate misspecification. Here, we summarize the role of oriented cell division during animal development and also outline the cellular and molecular mechanisms in selected invertebrate and vertebrate systems.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Growth and Development (Cabernard)
UniBasel Contributors:Cabernard, Clemens
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0960-9822
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:38

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