Misleading score-lines on tablets : facilitated intake or fractional dosing?

Arnet, Isabelle and Hersberger, Kurt E.. (2010) Misleading score-lines on tablets : facilitated intake or fractional dosing? Swiss Medical Weekly, 140 (7-8). pp. 105-110.

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Official URL: http://edoc.unibas.ch/dok/A5841040

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We selected the tablets mentioned as "scored" in the Swiss Compendium Online and in the Drug Formulary of Basel University Hospital, and screened the corresponding SPCs and PLs for information on divisibility and fractional dosing. Missing information was obtained from the drug marketing licence holder.; The Swiss Compendium Online contained 698 different scored tablets whose SPCs mentioned fractional dosing for 43.8% and explicitly forbade it for 2.7%. The Hospital Drug Formulary indexed 188 items as scored tablets. The corresponding SPCs mentioned fractional dosing for 107 (59.4%) and a sentence forbidding it for 5 (2.8%). The manufacturers' answers permitted fractional dosing for 49 (27.2%) of the remaining tablets and forbade it for 19 (10.5%). Lack of dosage uniformity or presence of "historic decorative" score-lines were the reasons given.; For the majority of scored tablets the official sources of drug information contained no explicit indication on fractional dosing. Improvement of splitting information is necessary to avoid potential medication errors.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmaceutical Care (Hersberger)
UniBasel Contributors:Hersberger, Kurt E. and Arnet, Isabelle
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:EMH Schweizerischer Arzteverlag
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Nov 2017 14:54
Deposited On:08 Jun 2012 06:51

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