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Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease

Wollmer, M. Axel and Papassotiropoulos, Andreas and Streffer, Johannes R. and Grimaldi, Luigi M. E. and Kapaki, Elisabeth and Salani, Giuliana and Paraskevas, George P. and Maddalena, Alessia and de Quervain, Dominique and Bieber, Claudia and Umbricht, Daniel and Lemke, Ulrike and Bosshardt, Simone and Degonda, Nadia and Henke, Katharina and Hegi, Thomas and Jung, Hans H. and Pasch, Thomas and Hock, Christoph and Nitsch, Roger M.. (2002) Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Psychiatric Genetics, Vol. 12, H. 3. pp. 155-160.

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Official URL: http://edoc.unibas.ch/dok/A5257190

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Abstract

Tissue inhibitor of metalloproteinases 1 (TIMP-1) inhibits several proteinases including a disintegrin and metalloproteinase 10 (ADAM10), a major alpha-secretase that cleaves the beta-amyloid precursor protein within its amyloidogenic Abeta domain. The gene encoding TIMP-1 (TIMP 1) maps to the short arm of the X chromosome, in a region previously suggested as conferring genetic susceptibility for Alzheimer's disease (AD). To determine whether genetic variability of TIMP 1 contributes to the pathogenesis of AD, we analysed one single nucleotide polymorphism within TIMP 1 and one single nucleotide polymorphism in the 5'-untranslated region of TIMP 1 in patients with AD and control subjects from two independent and ethnically different populations. We did not observe any association between TIMP 1 genotypes and the diagnosis of AD in men or women. We also measured TIMP-1 protein levels in the cerebrospinal fluid of patients with AD, healthy control subjects, and patients with other neurological disorders. TIMP-1 levels were similar in all groups. In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0955-8829
e-ISSN:1473-5873
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2017 10:59
Deposited On:22 Mar 2012 13:17

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