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Dpp Signaling Directs Cell Motility and Invasiveness during Epithelial Morphogenesis

Ninov, N. and Menezes-Cabral, S. and Prat-Rojo, C. and Manjón, C. and Weiss, A. and Pyrowolakis, G. and Affolter, M. and Martín-Blanco, E.. (2010) Dpp Signaling Directs Cell Motility and Invasiveness during Epithelial Morphogenesis. Current biology, Vol. 20. pp. 513-520.

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Official URL: http://edoc.unibas.ch/dok/A5842470

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Abstract

Tissue remodeling in development and disease involves the coordinated invasion of neighboring territories and/or the replacement of entire cell populations. Cell guidance, cell matching, transitions from passive to migratory epithelia, cell growth and death, and extracellular matrix remodeling all impinge on epithelial spreading. Significantly, the extracellular signals that direct these activities and the specific cellular elements and mechanisms regulated by these signals remain in most cases to be identified. To address these issues, we performed an analysis of histoblasts (Drosophila abdominal epithelial founder cells on their transition from a dormant state to active migration replacing obsolete larval epidermal cells (LECs)). We found that during expansion, Decapentaplegic (Dpp) secreted from surrounding LECs leads to graded pathway activation in cells at the periphery of histoblast nests. Across nests, Dpp activity confers differential cellular behavior and motility by modulating cell-cell contacts, the organization and activity of the cytoskeleton, and histoblast attachment to the substrate. Furthermore, Dpp also prevents the premature death of LECs, allowing the coordination of histoblast expansion to LEC delamination. Dpp signaling activity directing histoblast spreading and invasiveness mimics transforming growth factor-beta; and bone morphogenetic proteins` role in enhancing the motility and invasiveness of cancer cells, resulting in the promotion of metastasis.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0960-9822
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:56
Deposited On:08 Jun 2012 06:49

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