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Genetic association study on colony-stimulating factor 1 in Alzheimer's disease

Wollmer, M. Axel and Nitsch, Roger M. and Hock, Christoph and Papassotiropoulos, Andreas. (2006) Genetic association study on colony-stimulating factor 1 in Alzheimer's disease. Neuro-degenerative Diseases, 3 (6). pp. 334-337.

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Official URL: http://edoc.unibas.ch/dok/A5257158

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Abstract

BACKGROUND: Colony-stimulating factor 1 (CSF1) regulates the proliferation and differentiation of myelomonocytic cells. Microglial cells of CSF1-deficient mice are reduced in number and are functionally impaired. CSF1-deficient mice exhibit subtle neurodevelopmental defects, enhanced neuronal vulnerability. Moreover, it has been reported that these mice may have amyloid-plaque-like depositions in the brain at an early age. The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD. OBJECTIVE: We assessed if genetic variability of CSF1 may influence the risk for AD. METHODS: We conducted a population-based case-control association study with 3 single nucleotide polymorphisms (SNPs) across the CSF1 locus in a sample of n = 185 (rs3093054, rs756325) and n = 327 (rs1058885) individuals. RESULTS: None of the 3 investigated SNPs was associated with the risk for AD in our sample. CONCLUSION: These data do not support the hypothesis that genetic variability of CSF1 influences the risk for AD.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:1660-2854
e-ISSN:1660-2862
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:11 Oct 2017 13:10
Deposited On:22 Mar 2012 13:17

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