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The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

Sumara, Izabela and Vorlaufer, Elisabeth and Stukenberg, P. Todd and Kelm, Olaf and Redemann, Norbert and Nigg, Erich A. and Peters, Jan-Michael. (2002) The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Molecular cell, Vol. 9, H. 3. pp. 515-525.

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Official URL: http://edoc.unibas.ch/dok/A5249407

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Abstract

The separation of sister chromatids in anaphase depends on the dissociation of cohesin from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the onset of anaphase by proteolytic cleavage. In contrast, the bulk of cohesin is removed from chromosomes already in prophase and prometaphase by an unknown mechanism that does not involve cohesin cleavage. We show that Polo-like kinase is required for the cleavage-independent dissociation of cohesin from chromosomes in Xenopus. Cohesin phosphorylation depends on Polo-like kinase and reduces the ability of cohesin to bind to chromatin. These results suggest that Polo-like kinase regulates the dissociation of cohesin from chromosomes early in mitosis.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Nigg)
UniBasel Contributors:Nigg, Erich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:1097-2765
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:17

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