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Sorl1 as an Alzheimer's disease predisposition gene?

Webster, Jennifer A. and Myers, Amanda J. and Pearson, John V. and Craig, David W. and Hu-Lince, Diane and Coon, Keith D. and Zismann, Victoria L. and Beach, Thomas and Leung, Doris and Bryden, Leslie and Halperin, Rebecca F. and Marlowe, Lauren and Kaleem, Mona and Huentelman, Matthew J. and Joshipura, Keta and Walker, Douglas and Heward, Christopher B. and Ravid, Rivka and Rogers, Joseph and Papassotiropoulos, Andreas and Hardy, John and Reiman, Eric M. and Stephan, Dietrich A.. (2008) Sorl1 as an Alzheimer's disease predisposition gene? Neuro-degenerative Diseases, 5 (2). pp. 60-64.

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Official URL: http://edoc.unibas.ch/dok/A5257148

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:1660-2854
e-ISSN:1660-2862
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:23 Oct 2017 14:24
Deposited On:22 Mar 2012 13:17

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