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A genome-wide survey of human short-term memory

Papassotiropoulos, A. and Henke, K. and Stefanova, E. and Aerni, A. and Müller, A. and Demougin, P. and Vogler, C. and Sigmund, J. C. and Gschwind, L. and Huynh, K.-D. and Coluccia, D. and Mondadori, C. R. and Hänggi, J. and Buchmann, A. and Kostic, V. and Novakovic, I. and van den Bussche, H. and Kaduszkiewicz, H. and Weyerer, S. and Bickel, H. and Riedel-Heller, S. and Pentzek, M. and Wiese, B. and Dichgans, M. and Wagner, M. and Jessen, F. and Maier, W. and de Quervain, D. J.-F.. (2011) A genome-wide survey of human short-term memory. Molecular psychiatry, 16 (2). pp. 184-192.

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Abstract

Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909 622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the alpha subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and Aerni, Amanda and Demougin, Philippe and Vogler, Christian and Gschwind, Leo and Huynh, Kim-Dung and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1359-4184
Note:Note: Published online 29 December 2009 -- Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:08 Nov 2017 07:23
Deposited On:08 Jun 2012 06:41

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