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Successful hepatitis B immunization in non- and low responding health care workers

Heininger, Ulrich and Gambon, Muriel and Gruber, Verena and Margelli, Daniela. (2010) Successful hepatitis B immunization in non- and low responding health care workers. Human vaccines, Vol. 6, H. 9. pp. 725-728.

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Official URL: http://edoc.unibas.ch/dok/A5843714

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Abstract

Health care workers (HCW) are at increased risk for acquisition of hepatitis B virus (HBV) infection from occupational exposure. This can be prevented by active immunization. We performed a retrospective chart review of HCW who were persistent low (anti-HBs antibody values >100 U/L) or non responders (>10 U/L) after 6 active immunizations and demonstrate successful immunization (anti-HBs ?100 U/l) after a total of 8-14 vaccine doses in 13 such HCW by use of various vaccination schedules. This "proof of principle" should encourage occupational health care providers to convince HCW to accept further vaccine doses until the targeted threshold considered to be the correlate of immunity has been reached. Prospective studies should be performed to determine the optimal schedule of further booster doses for HCW who are persistent non or low responders.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine
UniBasel Contributors:Heininger, Ulrich
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Landes Bioscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:31
Deposited On:08 Jun 2012 06:30

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