How to reduce superoxide anion concentration using antioxidant nanoreactors

Balasubramanian, Vimalkumar and Onaca, Ozana and Axthelm, Fabian and Hughes, David and Grzelakowski, Mariusz and Meier, Wolfgang and Palivan, Cornelia. (2009) How to reduce superoxide anion concentration using antioxidant nanoreactors. Journal of Optoelectronics and Advanced Materials, 1 (6). pp. 1083-1087.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5253817

Downloads: Statistics Overview


In order to fight oxidative stress we developed antioxidant nanoreactors based on encapsulation of Cu/Zn superoxide dismutase or its mimics in amphiphilic copolymer nanovesicles whose membranes are oxygen permeable. The nanovesicles, made of poly-(2methyloxazoline)poly(dimethylsiloxane)-poly(2-methyloxazoline), successfully encapsulated the protein/mimics during their self-assembly process and were stable for more than one month. Testing with superoxide anions generated by pulse radiolysis demonstrated that the antioxidant agent remains active inside the nanovesicles and detoxifies the superoxide radical in situ. The triblock copolymer membrane of our nanovesicle plays a double role: both to shield the sensitive protein and to selectively allow superoxide and dioxygen to penetrate to the inner space of the vesicle. A simple and robust system, the antioxidant nanoreactor represents a new direction for developing medical applications for the treatment of oxidative stress.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P. and Palivan, Cornelia G and Balasubramanian, Vimalkumar and Onaca, Ozana
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:10 Apr 2017 07:58
Deposited On:22 Mar 2012 14:12

Repository Staff Only: item control page