Reduced activity of locus coeruleus neurons in hypertensive rats

Olpe, H. R. and Berecek, K. and Jones, R. S. G. and Steinmann, M. W. and Sonnenburg, Ch. and Hofbauer, K. G.. (1985) Reduced activity of locus coeruleus neurons in hypertensive rats. Neuroscience Letters, 61 (1-2). pp. 25-29.

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Official URL: http://edoc.unibas.ch/dok/A5258662

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The influence of blood pressure on locus coeruleus (LC) neuronal activity was investigated in chloral hydrate anesthetized rats. Mean spontaneous firing rate of LC neurons was reduced by 25% in deoxycorticosterone acetate (DOCA-salt) treated Sprague-Dawley rats and by 19% in spontaneously hypertensive rats (SHR) as compared to their corresponding control animals. In acute experiments performed on normotensive rats, peripherally induced blood pressure changes elicited reciprocal changes in cell firing of the majority of LC neurons. The findings suggest that LC may have a role in long-term regulation of blood pressure.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Sep 2023 13:58
Deposited On:22 Mar 2012 14:10

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