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Synthesis of Fmoc-Pro-Hyp(TBDPS)-Gly-OH and its Application as a Versatile Building Block for the Preparation of Collagen Model Peptides

Erdmann, Roman S. and Wennemers, Helma. (2009) Synthesis of Fmoc-Pro-Hyp(TBDPS)-Gly-OH and its Application as a Versatile Building Block for the Preparation of Collagen Model Peptides. Synthesis, 2009, H. 1. pp. 143-147.

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Official URL: http://edoc.unibas.ch/dok/A5262571

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Abstract

The efficient synthesis of the tripeptidic building block Fmoc-Pro-Hyp(TBDPS)-Gly-OH and its application for the prepa- ration of collagen model peptides (CMPs) has been achieved. The silyl ether protecting group prevents undesired side reactions during the CMP synthesis thereby facilitating purification and allowing for selective deprotection of the hydroxyproline residue without affect- ing the solid-supported CMP.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Bioorganische Chemie (Wennemers)
UniBasel Contributors:Wennemers, Helma
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Georg Thieme
ISSN:0039-7881
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:29
Deposited On:22 Mar 2012 14:07

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