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Calcein release from polymeric vesicles in blood plasma and PVA hydrogel

Litvinchuk, S. and Lu, Z. and Rigler, P. and Hirt, T. D. and Meier, W.. (2009) Calcein release from polymeric vesicles in blood plasma and PVA hydrogel. Pharmaceutical research, Vol. 26, H. 7. pp. 1711-1717.

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Official URL: http://edoc.unibas.ch/dok/A5251053

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Abstract

The main goal of this study was to show the long-term stability of vesicles from poly(2-methyl oxazoline-block-polydimethylsiloxane-block poly(2-methyl oxazoline) (PMOXA-PDMS-PMOXA) in PBS, blood plasma and the feasibility to use these vesicles for drug release from PVA hydrogels. The vesicle formation properties and loading efficiency was evaluated using fluorescent dyes. The stability of the vesicles was evaluated in buffer at pH 7 at room temperature and in 50 degrees C. The calcein loaded vesicles were dispersed in a UV crosslinked PVA hydrogel. The stability of the vesicles in the hydrogel was observed over one week, before the vesicles were ruptured with Triton X-100. The vesicles are very stable in buffer, blood plasma, and the PVA hydrogel. In plasma 50 presence of sodium azide. The vesicles can be evenly dispersed in PVA and are stable. The release can be triggered and the calcein diffuses afterwards quickly throughout the gel. Polymeric vesicles can be used as diffusion barrier in hydrogels for the controlled release of water soluble drugs.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Plenum Press
ISSN:0724-8741
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:29
Deposited On:22 Mar 2012 14:06

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