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Cartilage tissue engineering for degenerative joint disease

Nesic, Dobrila and Whiteside, Robert and Brittberg, Mats and Wendt, David and Martin, Ivan and Mainil-Varlet, Pierre. (2006) Cartilage tissue engineering for degenerative joint disease. Advanced drug delivery reviews, 58 (2). pp. 300-322.

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Abstract

Pain in the joint is often due to cartilage degeneration and represents a serious medical problem affecting people of all ages. Although many, mostly surgical techniques, are currently employed to treat cartilage lesions, none has given satisfactory results in the long term. Recent advances in biology and material science have brought tissue engineering to the forefront of new cartilage repair techniques. The combination of autologous cells, specifically designed scaffolds, bioreactors, mechanical stimulations and growth factors together with the knowledge that underlies the principles of cell biology offers promising avenues for cartilage tissue regeneration. The present review explores basic biology mechanisms for cartilage reconstruction and summarizes the advances in the tissue engineering approaches. Furthermore, the limits of the new methods and their potential application in the osteoarthritic conditions are discussed.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tissue Engineering (Martin)
UniBasel Contributors:Martin, Ivan
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0169-409x
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:23 Nov 2017 05:52
Deposited On:22 Mar 2012 13:59

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