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Interferon alpha 2a in IRPB-derived peptide-induced EAU--part I

Stübiger, Nicole and Crane, Isabel J. and Kötter, Ina and Lamont, Graeme R. and Zoeller, Margot and Günthert, Ursula and Forrester, John V. and Zierhut, Manfred and Stiemer, Rainer H.. (2003) Interferon alpha 2a in IRPB-derived peptide-induced EAU--part I. Advances in experimental medicine and biology, Vol. 528. pp. 537-540.

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Official URL: http://edoc.unibas.ch/dok/A5249203

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Abstract

Clinically, the IFN-α treated animals exhibited minimal disease, compared to the control group. These findings have been histologically confirmed. Using a variety of monoclonal antibodies, we were not able to demonstrate any differences for panCD44 expression. The similar expression pattern of panCD44 in the retina between control and IFN-α treated mice indicates that this expression may be not influenced by the applied IFN-α dosage. The panCD44 homing receptor may be important for the regulation of EAU induction by CD45+ and CD3+ T-cells. Differences have been observed for CD45+ infiltration between control and IFN-α treated animals. This may be an important hint to characterize their function by markers others than CD8 and CD4 specific antibodies, especially for their T-cell receptor (TCR) expression (α/β versus γ/δ). To identify further differences between IFN-α treated and control mice our analyses will be extended to antigen presenting cells (APC), especially to dendritic cells (DC) capable to regulate the Th1/Th2 balance. Additionally, these analyses will be extended to cell adhesion molecules and/or homing receptor expression kinetics regulated by chemo-and cytokines. EAU induction experiments are presently performed with an increased IFN-α dosage correlating with the surface (m2) of human beings to clarify our results.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Neuro- und Muskelpathologie (Frank)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Neuro- und Muskelpathologie (Frank)
UniBasel Contributors:Günthert, Ursula
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0065-2598
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:27
Deposited On:22 Mar 2012 13:59

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