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Nonylphenol affects the granulation pattern of epidermal mucous cells in rainbow trout, Oncorhynchus mykiss

Burkhardt-Holm, P. and Wahli, T. and Meier, W.. (2000) Nonylphenol affects the granulation pattern of epidermal mucous cells in rainbow trout, Oncorhynchus mykiss. Ecotoxicology and Environmental Safety, 46 (1). pp. 34-40.

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Official URL: http://edoc.unibas.ch/dok/A5252600

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Abstract

Nonylphenol is a biodegradation product of nonionic surfactants and has recently attracted considerable attention due to its estrogenic potential. Sexually mature male rainbow trout were repeatedly exposed (one to four periods of 10 days each) to environmentally relevant concentrations of nonylphenol (1 microg/L, 10 microg/L) and for comparison, trout were injected with estradiol. Since estrogens are known to induce structural changes within the fish skin, a similar effect of xenobiotics with estrogen-like activity was assumed. Samples of skin were evaluated by means of light and electron microscopy and histochemistry. In trout exposed to nonylphenol and to estradiol, the structure of the epidermis was altered: an irregular overall architecture was often accompanied by detached pavement cells, vacuolation of the cytoplasm, and severely deformed cell nuclei. However, the granulation pattern of the mucous cells was influenced exclusively after exposition to nonylphenol. The number of large and irregularly shaped mucosomes depended more on the exposure period than on the concentration of nonylphenol. Furthermore, this alteration has not yet been reported for any other pollutant or stressor and, thus, can be classified as an effect that would strongly indicate exposure to nonylphenol.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Mensch Gesellschaft Umwelt MGU > Aquatische ├ľkologie (Holm)
UniBasel Contributors:Holm, Patricia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Academic Press
ISSN:1090-2414
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Nov 2017 12:53
Deposited On:22 Mar 2012 13:57

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