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Therapy-induced plasticity of cognitive functions in MS patients : insights from fMRI

Penner, I. -K. and Kappos, L. and Rausch, M. and Opwis, K. and Radü, E. W.. (2006) Therapy-induced plasticity of cognitive functions in MS patients : insights from fMRI. Journal of physiology - Paris, Vol. 99. pp. 455-462.

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Official URL: http://edoc.unibas.ch/dok/A5249023

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Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system whose pathological mechanisms are still not completely understood. Physical as well as cognitive deterioration are consequences within the disease process that have an extensive impact on the patient's quality of life. Therefore, understanding the functional background of spontaneous as well as induced remission is of high relevance. Studies on visualization of therapeutic effects of pharmacological or cognitive treatment by functional magnetic resonance imaging (fMRI) are still rare. From fMRI studies on focal brain lesions hypotheses on mechanisms of brain reorganization can be derived. This contribution will first give an overview of the existing studies using fMRI in MS, on cognitive decline, on cognitive treatment studies and its therapeutic effects on behavioural readouts in MS, and on therapy-induced brain plasticity and its possible visualization by fMRI. Results of a study on correlating the effects of cognitive training with changes in brain organization in patients with mild to severe cognitive impairment will be reported. (c) 2006 Elsevier Ltd. All rights reserved.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Persönlichkeits- und Entwicklungspsychologie > Allgemeine Psychologie und Methodologie (Opwis)
UniBasel Contributors:Opwis, Klaus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0928-4257
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:26
Deposited On:22 Mar 2012 13:52

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