Items where Author is "Witty, M. J."

2022

Smith, A. and Wall, R. J. and Patterson, S. and Rowan, T. and Rico Vidal, E. and Stojanovski, L. and Huggett, M. and Hampton, S. E. and Thomas, M. G. and Corpas Lopez, V. and Gillingwater, K. and Duke, J. and Napier, G. and Peter, R. and Vitouley, H. S. and Harrison, J. R. and Milne, R. and Jeacock, L. and Baker, N. and Davis, S. H. and Simeons, F. and Riley, J. and Horn, D. and Brun, R. and Zuccotto, F. and Witty, M. J. and Wyllie, S. and Read, K. D. and Gilbert, I. H.. (2022) Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for Use in the TREATMENT of African animal trypanosomiasis. Journal of medicinal chemistry, 65 (7). pp. 5606-5624.

2017

Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic and Medicinal Chemistry Letters, 28. pp. 6-10.

2012

Younis, Y. and Douelle, F. and Feng, T. S. and Cabrera, D. G. and Manach, C. L. and Nchinda, A. T. and Duffy, S. and White, K. L. and Shackleford, D. M. and Morizzi, J. and Mannila, J. and Katneni, K. and Bhamidipati, R. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Hardick, D. and Wittlin, S. and Avery, V. and Charman, S. A. and Chibale, K.. (2012) 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. Journal of medicinal chemistry, 55 (7). pp. 3479-3487.

González, Cabrera and Douelle, F. and Younis, Y. E. and Feng, T. S. and Lemanach, C. and Nchinda, A. T. and Street, L. J. and Scheurer, C. and Kamber, J. and White, K. L. and Montagnat, O. D. and Ryan, E. and Katneni, K. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Charman, S. A. and Wittlin, S. and Chibale, K.. (2012) Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines. Journal of medicinal chemistry, 55 (24). pp. 11022-11030.

2011

González Cabrera D., and Douelle, F. and Feng, T. S. and Nchinda, A. T. and Younis, Y. and White, K. L. and Wu, Q. and Ryan, E. and Burrows, J. N. and Waterson, D. and Witty, M. J. and Wittlin, S. and Charman, S. A. and Chibale, K.. (2011) Novel orally active antimalarial thiazoles. Journal of medicinal chemistry, 54 (21). pp. 7713-7719.

2009

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 481-484.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 401-405.