Items where Author is "Jakob, Roman P."

2023

Isaikina, Polina and Petrovic, Ivana and Jakob, Roman P. and Sarma, Parishmita and Ranjan, Ashutosh and Baruah, Minakshi and Panwalkar, Vineet and Maier, Timm and Shukla, Arun K. and Grzesiek, Stephan. (2023) A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Molecular cell, 83 (12). pp. 2108-2121.e7.

2022

Miller, Ryan D. and Iinishi, Akira and Modaresi, Seyed Majed and Yoo, Byung-Kuk and Curtis, Thomas D. and Lariviere, Patrick J. and Liang, Libang and Son, Sangkeun and Nicolau, Samantha and Bargabos, Rachel and Morrissette, Madeleine and Gates, Michael F. and Pitt, Norman and Jakob, Roman P. and Rath, Parthasarathi and Maier, Timm and Malyutin, Andrey G. and Kaiser, Jens T. and Niles, Samantha and Karavas, Blake and Ghiglieri, Meghan and Bowman, Sarah E. J. and Rees, Douglas C. and Hiller, Sebastian and Lewis, Kim. (2022) Computational identification of a systemic antibiotic for gram-negative bacteria. Nature Microbiology, 7 (10). pp. 1661-1672.

Tittes, Yves U. and Herbst, Dominik A. and Martin, Solène F. X. and Munoz-Hernandez, Hugo and Jakob, Roman P. and Maier, Timm. (2022) The structure of a polyketide synthase bimodule core. Science Advances, 8 (38). eabo6918.

2021

Tomašič, Tihomir and Rabbani, Said and Jakob, Roman P. and Reisner, Andreas and Jakopin, Žiga and Maier, Timm and Ernst, Beat and Anderluh, Marko. (2021) Does targeting Arg98 of FimH lead to high affinity antagonists? European Journal of Medicinal Chemistry, 211. p. 113093.

Pipercevic, Joka and Jakob, Roman P. and Righetto, Ricardo D. and Goldie, Kenneth N. and Stahlberg, Henning and Maier, Timm and Hiller, Sebastian. (2021) Identification of a Dps contamination in Mitomycin-C-induced expression of Colicin Ia. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863 (7). p. 183607.

Böhringer, Nils and Green, Robert and Liu, Yang and Mettal, Ute and Marner, Michael and Modaresi, Seyed Majed and Jakob, Roman P. and Wuisan, Zerlina G. and Maier, Timm and Iinishi, Akira and Hiller, Sebastian and Lewis, Kim and Schäberle, Till F.. (2021) Mutasynthetic Production and Antimicrobial Characterization of Darobactin Analogs. Microbiology spectrum, 9 (3). e0153521.

Cramer, Jonathan and Lakkaichi, Adem and Aliu, Butrint and Jakob, Roman P. and Klein, Sebastian and Cattaneo, Ivan and Jiang, Xiaohua and Rabbani, Said and Schwardt, Oliver and Zimmer, Gert and Ciancaglini, Matias and Abreu Mota, Tiago and Maier, Timm and Ernst, Beat. (2021) Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. Journal of the American Chemical Society, 143 (42). pp. 17465-17478.

Kaur, Hundeep and Jakob, Roman P. and Marzinek, Jan K. and Green, Robert and Imai, Yu and Bolla, Jani Reddy and Agustoni, Elia and Robinson, Carol V. and Bond, Peter J. and Lewis, Kim and Maier, Timm and Hiller, Sebastian. (2021) The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase. Nature, 593 (7857). pp. 125-129.

Böhm, Raphael and Imseng, Stefan and Jakob, Roman P. and Hall, Michael N. and Maier, Timm and Hiller, Sebastian. (2021) The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1. Molecular Cell, 81 (11). pp. 2403-2416.e5.

2020

Righetto, Ricardo D. and Anton, Leonie and Adaixo, Ricardo and Jakob, Roman P. and Zivanov, Jasenko and Mahi, Mohamed-Ali and Ringler, Philippe and Schwede, Torsten and Maier, Timm and Stahlberg, Henning. (2020) Author Correction: High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica. Nature Communications, 11 (1). p. 5873.

Righetto, Ricardo D. and Anton, Leonie and Adaixo, Ricardo and Jakob, Roman P. and Zivanov, Jasenko and Mahi, Mohamed-Ali and Ringler, Philippe and Schwede, Torsten and Maier, Timm and Stahlberg, Henning. (2020) High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica. Nature Communications, 11 (1). p. 5101.

Künzli, Marco and Schreiner, David and Pereboom, Tamara C. and Swarnalekha, Nivedya and Litzler, Ludivine C. and Lötscher, Jonas and Ertuna, Yusuf I. and Roux, Julien and Geier, Florian and Jakob, Roman P. and Maier, Timm and Hess, Christoph and Taylor, Justin J. and King, Carolyn G.. (2020) Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity. Science Immunology, 5 (45). eaay5552.

Brunner, Janine D. and Jakob, Roman P. and Schulze, Tobias and Neldner, Yvonne and Moroni, Anna and Thiel, Gerhard and Maier, Timm and Schenck, Stephan. (2020) Structural basis for ion selectivity in TMEM175 K+ channels. eLife, 9. p. 53683.

2019

Sauer, Maximilian M. and Jakob, Roman P. and Luber, Thomas and Canonica, Fabia and Navarra, Giulio and Ernst, Beat and Unverzagt, Carlo and Maier, Timm and Glockshuber, Rudi. (2019) Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets. Journal of the American Chemical Society, 141 (2). pp. 936-944.

Kaur, Hundeep and Hartmann, Jean-Baptiste and Jakob, Roman P. and Zahn, Michael and Zimmermann, Iwan and Maier, Timm and Seeger, Markus A. and Hiller, Sebastian. (2019) Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. Journal of Biomolecular NMR, 73. pp. 375-384.

Schönemann, Wojciech and Cramer, Jonathan and Mühlethaler, Tobias and Fiege, Brigitte and Silbermann, Marleen and Rabbani, Said and Dätwyler, Philipp and Zihlmann, Pascal and Jakob, Roman P. and Sager, Christoph P. and Smiesko, Martin and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2019) Improvement of Aglycone π-Stacking Yields Nano- to Subnanomolar FimH Antagonists. ChemMedChem, 14 (7). pp. 749-757.

2018

Bauer, Daniela and Meinhold, Sarah and Jakob, Roman P. and Stigler, Johannes and Merkel, Ulrich and Maier, Timm and Rief, Matthias and Žoldák, Gabriel. (2018) A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 115 (18). pp. 4666-4671.

Vigano, M. Alessandra and Bieli, Dimitri and Schaefer, Jonas V. and Jakob, Roman P. and Matsuda, Shinya and Maier, Timm and Plückthun, Andreas and Affolter, Markus. (2018) Correction:DARPins recognizing mTFP1 as novel reagents for in vitro; and in vivo protein manipulations. Biology open, 7 (12). bio036749.

Zihlmann, Pascal and Silbermann, Marleen and Sharpe, Timothy and Jiang, Xiaohua and Mühlethaler, Tobias and Jakob, Roman P. and Rabbani, Said and Sager, Christoph P. and Frei, Priska and Pang, Lijuan and Maier, Timm and Ernst, Beat. (2018) KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24. pp. 1-10.

Sager, Christoph P. and Fiege, Brigitte and Zihlmann, Pascal and Vannam, Raghu and Rabbani, Said and Jakob, Roman P. and Preston, Roland C. and Zalewski, Adam and Maier, Timm and Peczuh, Mark W. and Ernst, Beat. (2018) The price of flexibility - a case study on septanoses as pyranose mimetics. Chemical Science, 9 (3). pp. 646-654.

Herbst, Dominik A. and Huitt-Roehl, Callie R. and Jakob, Roman P. and Kravetz, Jacob M. and Storm, Philip A. and Alley, Jamie R. and Townsend, Craig A. and Maier, Timm. (2018) The structural organization of substrate loading in iterative polyketide synthases. Nature Chemical Biology, 14 (5). 474–479.

2017

Navarra, Giulio and Zihlmann, Pascal and Jakob, Roman P. and Stangier, Katia and Preston, Roland C. and Rabbani, Said and Smiesko, Martin and Wagner, Bea and Maier, Timm and Ernst, Beat. (2017) Carbohydrate-Lectin Interactions - An Unexpected Contribution to Affinity. ChemBioChem, 18 (6). pp. 539-544.

24 March 2016

Herbst, Dominik A. and Jakob, Roman P. and Zähringer, Franziska and Maier, Timm. (2016) Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. Nature, 531 (7595). pp. 533-537.

February 2016

Preston, Roland C. and Jakob, Roman P. and Binder, Florian P. C. and Sager, Christoph P. and Ernst, Beat and Maier, Timm. (2016) E-selectin ligand complexes adopt an extended high-affinity conformation. Journal of Molecular Cell Biology, 8 (1). pp. 62-72.

2016

Sauer, Maximilian M. and Jakob, Roman P. and Eras, Jonathan and Baday, Sefer and Eris, Deniz and Navarra, Giulio and Bernèche, Simon and Ernst, Beat and Maier, Timm and Glockshuber, Rudi. (2016) Catch-bond mechanism of the bacterial adhesin FimH. Nature communications, 7. p. 10738.

Jakob, Roman P. and Schmidpeter, Philipp A. M. and Koch, Johanna R. and Schmid, Franz X. and Maier, Timm. (2016) Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps. PLoS ONE, 11 (6). e0157070.

2015

Jakob, Roman P. and Koch, Johanna R. and Burmann, Björn M. and Schmidpeter, Philipp A. M. and Hunkeler, Moritz and Hiller, Sebastian and Schmid, Franz X. and Maier, Timm. (2015) Dimeric structure of the bacterial extracellular foldase PrsA. Journal of Biological Chemistry, 290 (6). pp. 3278-3292.

Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239.

Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246.

2014

Bukhari, Habib S. T. and Jakob, Roman P. and Maier, Timm. (2014) Evolutionary origins of the multienzyme architecture of giant fungal Fatty Acid synthase. Structure, 22 (12). pp. 1775-1785.

2013

Gruss, Fabian and Zähringer, Franziska and Jakob, Roman P. and Burmann, Björn M. and Hiller, Sebastian and Maier, Timm. (2013) The structural basis of autotransporter translocation by TamA. Nature structural & molecular biology, Vol. 20, no. 11. pp. 1318-1320.