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Der klinisch-pharmakologische Fall (2) = [Clinico-pharmacological case (2)] : Bradykardie und ventrikuläre Tachykardie vom Typ Torsade de pointes als Nebenwirkung von Vasopressin : drei Fallberichte : Bradycardia and ventricular tachycardia of the torsades de pointes type as a side effect of vasopressin : three case reports

Kupferschmidt, H. and Meier, C. H. and Sulzer, M. and Meier, P. J. and Bühler, H.. (1996) Der klinisch-pharmakologische Fall (2) = [Clinico-pharmacological case (2)] : Bradykardie und ventrikuläre Tachykardie vom Typ Torsade de pointes als Nebenwirkung von Vasopressin : drei Fallberichte : Bradycardia and ventricular tachycardia of the torsades de pointes type as a side effect of vasopressin : three case reports. Schweizerische Rundschau für Medizin Praxis, 85, Nr. 11. S. 340-343.

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Official URL: http://edoc.unibas.ch/dok/A5261734

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Abstract

We present three patients with ornipressin-induced bradycardia, one of which developed also ventricular tachycardia of the torsade de pointes type. All three patients were treated with this vasopressin derivative because of bleeding esophageal varices due to portal hypertension in liver cirrhosis. Bradycardia ceased after discontinuing ornipressin therapy. One patient was treated successfully with atropine, one with isoprenalin and magnesium (he had to be defibrillated); the third patient recovered after cessation of ornipressin administration. Bradycardia is a known but rarely reported side effect of vasopressin and its derivatives. Animal studies suggest that this effect is due to its cardiodepressive action and also to a vagus-mediated reflex following vasopressin-induced increase in blood pressure. When injected directly into the ventricles of the brain, vesopressin leads to a decrease of the heart rate without affecting blood pressure; however, it remains unclear whether this mechanism is responsible for bradycardia after intravenous administration. Careful monitoring is essential during the treatment with vasopressin and its derivatives.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Bibsysno:Link to catalogue
ISSN:0369-8394
Note:Note: Zusammenfassung engl./franz. -- Publication type according to Uni Basel Research Database: Journal item
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Last Modified:08 Jun 2012 06:29
Deposited On:22 Mar 2012 13:38

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