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Dehydroepiandrosterone sulfate (DHEAS) : identification of a carrier protein in human liver and brain

Kullak-Ublick, G. A. and Fisch, T. and Oswald, M. and Hagenbuch, B. and Meier, P. J. and Beuers, U. and Paumgartner, G.. (1998) Dehydroepiandrosterone sulfate (DHEAS) : identification of a carrier protein in human liver and brain. FEBS letters, Vol. 424, H. 3. S. 173-176.

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Official URL: http://edoc.unibas.ch/dok/A5261710

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Abstract

Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man. Pharmacologically, it exerts marked neuropsychiatric effects. Since no target receptor has been identified, we investigated whether the organic anion transporting polypeptide (OATP), a multispecific steroid carrier, transports DHEAS. Expression of the human liver OATP in Xenopus laevis oocytes resulted in high-affinity, partially Na+-dependent uptake of [3H]DHEAS (Km: 6.6 micromol/l). DHEAS transport was inhibited by bromosulfophthalein, bile acids, sulfated estrogens and dexamethasone. Northern blot analysis showed widespread expression of OATP in human brain. These data identify OATP as the first known target protein of DHEAS in human liver and brain.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0014-5793
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:35

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