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A developmental switch in the response of DRG neurons to ETS transcription factor signaling

Hippenmeyer, S. and Vrieseling, E. and Sigrist, M. and Portmann, T. and Laengle, C. and Ladle, D. R. and Arber, S.. (2005) A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biology, Vol. 3, H. 5 , e159.

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Official URL: http://edoc.unibas.ch/dok/A5259078

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Abstract

Two ETS transcription factors of the Pea3 subfamily are induced in subpopulations of dorsal root ganglion (DRG) sensory and spinal motor neurons by target-derived factors. Their expression controls late aspects of neuronal differentiation such as target invasion and branching. Here, we show that the late onset of ETS gene expression is an essential requirement for normal sensory neuron differentiation. We provide genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support. Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Public Library of Science
ISSN:1545-7885
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:09 Jan 2015 09:25
Deposited On:22 Mar 2012 13:32

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