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Induction of drug-metabolizing enzymes by phenobarbitone : structural and biochemical aspects

Meyer, U. A. and Meier, P. J. and Hirsiger, H. and Giger, U. and Althaus, F. R.. (1980) Induction of drug-metabolizing enzymes by phenobarbitone : structural and biochemical aspects. Ciba Foundation symposium. New series, 76. S. 101-118.

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Official URL: http://edoc.unibas.ch/dok/A5261819

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Abstract

Two aspects of the induction of microsomal monooxygenases by phenobarbitone have been investigated. First, structural associations between mitochondria and single cisternae of rough endoplasmic reticulum (mitochondria--RER complexes) may operate as functional units in the biosynthesis of cytochrome P-450. This was deduced from (i) studies on the subcellular distribution of the phenobarbitone-induced incorporation of leucine into microsomal proteins including apocytochromes P-450 and (ii) the incorporation of labelled delta-aminolaevulinic acid into the haem prosthetic group of cytochrome P-450. Secondly, in hepatocytes from chick embryo in primary monolayer culture, induction of cytochrome P-450-haemoproteins was markedly influenced by changes in the proliferative activity of hepatocytes. Inducibility of cytochrome P-450 by phenobarbitone and by beta-naphthoflavone was decreased in cultures with 'spontaneous' or experimentally increased proliferative activity of hepatocytes. Treatment with inhibitors of DNA synthesis increased the induction response.
Faculties and Departments:11 Rektorat und Verwaltung > Vizerektorat Forschung
UniBasel Contributors:Meier-Abt, Peter J.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Note:Also published in: Environmental chemicals, enzyme function and human disease. - Amsterdam : Excerpta Medica. - S. 101-118 -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:30

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