edoc

The ACC is a critical hub for neuropathic pain- induced depression

Sellmeijer, Jim. The ACC is a critical hub for neuropathic pain- induced depression. 2016, PhD Thesis, University of Basel, Faculty of Science.

[img] PDF
Restricted to Repository staff only until 2 November 2017.

17Mb

Official URL: http://edoc.unibas.ch/diss/DissB_11965

Downloads: Statistics Overview

Abstract

Besides chronic stress, chronic pain is one of the prevalent determinants for depression. Indeed,
around 50% of chronic pain patients develop mood disorders. Alterations in brain regions
implicated in pain processing may also be involved in affective processing, thus potentially be
responsible of mood disorders. However, the underlying mechanisms of this comorbidity are not
yet elucidated. Here, we studied the role of the anterior cingulate cortex (ACC) in the
somatosensory, aversive and anxiodepressive consequences of neuropathic pain. We showed that
a permanent lesion or temporal inhibition of ACC pyramidal neurons blocked the development or
suppressed the expression of an anxiodepressive phenotype in neuropathic mice. In addition,
anxiodepressive-like behavior coincided with ACC hyperactivity. In conclusion we show that the
ACC is a critical hub for neuropathic pain-induced depression.
Advisors:Luthi, Andreas and Aertsen, Ad and Yalçın-Christmann, İpek
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI > Neurobiology > Cellular mechanisms of learning and memory (Lüthi)
Item Type:Thesis
Thesis no:11965
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (113 Seiten)
Language:English
Identification Number:
Last Modified:21 Dec 2016 12:44
Deposited On:21 Dec 2016 12:44

Repository Staff Only: item control page