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Psychological and metabolic effects of dietary carbohydrates and dexfenfluramine during a low-energy diet in obese women

Kogon, M. M. and Kraeuchi, K. and Van der Velde, P. and Van der Werf, H. and Keller, U.. (1994) Psychological and metabolic effects of dietary carbohydrates and dexfenfluramine during a low-energy diet in obese women. American journal of clinical nutrition, Vol. 60, H. 4. S. 488-493.

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Official URL: http://edoc.unibas.ch/dok/A6419850

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Abstract

Dietary carbohydrates and dexfenfluramine (dF) have been shown to influence serotoninergic neurotransmission. To assess their effect on spontaneous physical activity, mood, sleep quality, and resting metabolic rate (RMR), 32 obese females were studied while consuming diets providing 3970 kJ (950 kcal)/d. They were randomly allocated to either a diet relatively high in carbohydrates (carbohydrate:fat:protein, 49%:22%:29% of energy intake; group 1) or to a diet relatively high in fat (carbohydrate:fat:protein, 12%:59%:29%); subjects receiving the latter diet were treated additionally with either 30 mg dF (group 2) or placebo (group 3) daily in a double-blind fashion. Spontaneous physical activity decreased in the group treated with dF compared with the other two groups (P = 0.0002). Daily self-rated questionnaires indicated that mood and tiredness were negatively affected in two groups after the first week. Subjects treated with dF lost more weight than did those in the other two groups (P = 0.013). This occurred despite a decrease in physical activity and unchanged energy intake and resting energy expenditure.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
UniBasel Contributors:Keller, Ulrich O.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:American Society for Clinical Nutrition
ISSN:0002-9165
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:02 Oct 2015 10:00
Deposited On:02 Oct 2015 10:00

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