Lu, Yun-Yueh. Modulation of host immune responses by Bartonella effector proteins. 2015, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_11262
In the second project, I focused on the natural host interface with Bartonella, particularly on the bacterial defense mechanisms against host immunity. To achieve this, my work was divided into two directions. One was to identify which Bartonella effector proteins as immunomodulatory molecules involved in intracellular communications to subvert the immunological signaling cascade. The other was to find the primary niche of Bartonella entry and replication in the natural reservoir host. By understanding the Bartonella infection cycle, I aimed to explore how Bartonella manipulate host immunity towards its pathogenicity in vivo. Taken in vitro and in vivo results together, I sought to complete this project with a comprehensive insight into which Bep displays immunosuppressive properties, how it works and what are the consequences of its function on host immunity.
|Committee Members:||Bumann, Dirk|
|Faculties and Departments:||05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Dehio)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||197 S.|
|Last Modified:||30 Jun 2016 10:57|
|Deposited On:||05 Aug 2015 12:50|
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