Nollmann, Friederike I. and Dauth, Christina and Mulley, Geraldine and Kegler, Carsten and Kaiser, Marcel and Waterfield, Nick R. and Bode, Helge B.. (2015) Insect-specific production of new GameXPeptides in Photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 16, H. 2. pp. 205-208.
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Official URL: http://edoc.unibas.ch/dok/A6338850
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Abstract
Discovery of new natural products by heterologous expression reaches its limits, especially when specific building blocks are missing in the heterologous host or the production medium. Here, we describe the insect-specific production of the new GameXPeptides E-H (5-8) from Photorhabdus luminescens TTO1, which can be produced heterologously from expression of the GameXPeptide synthetase GxpS only upon supplementation of the production media with the missing building blocks, and thus must be regarded as the true natural products under natural conditions.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley-VCH |
| ISSN: | 1439-4227 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 06 Feb 2015 09:59 |
| Deposited On: | 06 Feb 2015 09:59 |
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