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Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides.

Fei, Na and Häussinger, Daniel and Blümli, Seraina and Laventie, Benoît-Joseph and Bizzini, Lorenzo D. and Zimmermann, Kaspar and Jenal, Urs and Gillingham, Dennis. (2014) Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50 (62). pp. 8499-8502.

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Official URL: http://edoc.unibas.ch/dok/A6271987

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Abstract

We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development
05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Infection Biology
05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger)
UniBasel Contributors:Jenal, Urs and Laventie, Benoit-Joseph and Fei, Na and Blümli, Seraina and Delarue Bizzini, Lorenzo and Zimmermann, Kaspar and Gillingham, Dennis and Häussinger, Daniel
Item Type:Article, refereed
Publisher:Royal Society of Chemistry
ISSN:0022-4936
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:28 Nov 2016 15:00
Deposited On:06 Feb 2015 09:58

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