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Extract from brain stimulates neurite outgrowth from fetal rat retinal explants

Turner, J. E. and Barde, Y. A. and Schwab, M. E. and Thoenen, H.. (1982) Extract from brain stimulates neurite outgrowth from fetal rat retinal explants. Brain research, Vol. 282, H. 1. S. 77-83.

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Official URL: http://edoc.unibas.ch/dok/A5259582

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Abstract

Explants from rat fetal retina were placed in culture and assayed for fiber outgrowth. In contrast to results obtained with lower vertebrates, nerve growth factor (NGF) does not seem to play a role in this system: NGF is not able to stimulate fiber outgrowth and antibodies to NGF do not block the spontaneously occurring fiber outgrowth. However, an extract prepared from pig brain is able to stimulate fiber outgrowth in a dose-dependent manner. It is suggested that such an extract can be used as a source of putative neurotrophic factors exhibiting in the mammalian central nervous system (CNS) an action similar to that of NGF in the peripheral nervous system (PNS) of mammals and in the CNS of lower vertebrates like fishes and amphibia.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0006-8993
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

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