Abgottspon, Daniela. In vitro and in vivo characterization of FimH antagonists for anti-adhesion therapy - an alternative therapeutic approach against urinary tract infection. 2014, PhD Thesis, University of Basel, Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_11075
An alternative approach for the treatment of UTI is the anti-adhesion therapy using FimH antagonists. FimH is an adhesin, located on the distal tip of type 1 pili, expressed on the surface of UPEC. The type 1 pilus contains a carbohydrate recognition domain, binding to mannose glycans expressed on urothelial cells. This allows UPEC to adhere to and to invade host cells within the urinary tract epithelium and is the initial step for a successful establishment of a UTI.
FimH antagonists are highly active anti-adhesion molecules, targeting the virulence factor FimH. In vitro and in vivo studies clearly indicate the potential of FimH antagonists for the prevention and treatment of UTI, with a higher therapeutic efficacy compared to antibiotics.
The anti-adhesion therapy is focusing on the development of a new class of antimicrobials exhibiting less selection pressure and therefore a reduced potential for the emergence of resistance. In addition, a reduction of the antibiotic associated side effects (e.g. the disruption of the commensal microbiota) is expected. Thus, the availability of a novel class of antimicrobials based on an alternative mode of action would have a huge impact on the treatment of UTI, being a substantial contribution to public health.
|Committee Members:||Frimodt-Møller, Nils|
|Faculties and Departments:||05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Molekulare Pharmazie (Ernst)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||1 Vol.|
|Last Modified:||30 Jun 2016 10:56|
|Deposited On:||08 Jan 2015 07:43|
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