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10 year-follow up of cluster-based asthma phenotypes in adults : a pooled analysis of three cohorts

Boudier, Anne and Curjuric, Ivan and Basagaña, Xavier and Hazgui, Hana and Anto, Josep M. and Bousquet, Jean and Bridevaux, Pierre O. and Dupuis-Lozeron, Elise and Garcia-Aymerich, Judith and Heinrich, Joachim and Janson, Christer and Künzli, Nino and Leynaert, Bénédicte and de Marco, Roberto and Rochat, Thierry and Schindler, Christian and Varraso, Raphaëlle and Pin, Isabelle and Probst-Hensch, Nicole and Sunyer, Jordi and Kauffmann, Francine and Siroux, Valérie. (2013) 10 year-follow up of cluster-based asthma phenotypes in adults : a pooled analysis of three cohorts. American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, Vol. 188, H. 5. S. 550-560.

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Official URL: http://edoc.unibas.ch/dok/A6174363

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Abstract

Rationale: The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. Objectives: To compare the stability of cluster-based asthma phenotype structures a decade apart in adults and to address the individuals' phenotypic transition across these asthma phenotypes. Methods: The latent transition analysis was applied on longitudinal data (twice, 10 yr apart) from 3,320 adults with asthma who took part in the European Community Respiratory Health Survey, the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults, or the Epidemiological Study on Genetics and Environment of Asthma. Nine variables covering personal and phenotypic characteristics measured twice, 10 years apart, were simultaneously considered. Measurements and Main Results: Latent transition analysis identifies seven asthma phenotypes (prevalence range, 8.4-20.8%), mainly characterized by the level of asthma symptoms (low, moderate, high), the allergic status, and pulmonary function. Phenotypes observed 10 years apart showed strong similarities. The probability of membership in the same asthma phenotype at both times varied across phenotypes from 54 to 88%. Different transition patterns were observed across phenotypes. Transitions toward increased asthma symptoms were more frequently observed among nonallergic phenotypes as compared with allergic phenotypes. Results showed a strong stability of the allergic status over time. Conclusions: Adult asthma phenotypes identified by a clustering approach, 10 years apart, were highly consistent. This study is the first to model the probabilities of transitioning over time between comprehensive asthma phenotypes.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Schindler, Christian and Probst Hensch, Nicole
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:HighWire Press
ISSN:0003-0805
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

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