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Tumor-Nekrose-Faktor im Serum = Tumor necrosis factor in the serum : eine sinnvolle Ergänzung der Entzündungsdiagnostik bei Cystischer Fibrose? : a useful supplemental parameter in the diagnosis of infection in cystic fibrosis?

Heininger, U. and Böwing, B. and Forster, D. and Berthold, M.. (1991) Tumor-Nekrose-Faktor im Serum = Tumor necrosis factor in the serum : eine sinnvolle Ergänzung der Entzündungsdiagnostik bei Cystischer Fibrose? : a useful supplemental parameter in the diagnosis of infection in cystic fibrosis? Klinische Pädiatrie, Vol. 203, H. 3. S. 158-161.

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Official URL: http://edoc.unibas.ch/dok/A5839221

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Abstract

In 15 patients with cystic fibrosis 18 blood samples were investigated for signs of infection including full white blood count, c-reactive protein (CRP) and tumour-necrosis-factor alpha (TNF). Ten patients were hospitalized for pulmonary exacerbation, one for orthostatic collapse and one for equivalent of meconium ileus. The latter two as well as three out-patients with cystic fibrosis on routine-visits served as controls. Blood was taken on admission and at the time of the visit in our out-patient department, respectively. In three cases, blood was taken repeatedly during their stays in hospital. While leucocytosis (17.700 +/- 3.500) and elevated CRP-levels (6.4 +/- 7.3 mg/dl) pointed to an infectious cause of deterioration in the exacerbation-group, TNF-levels without exception were undetectable (less than 15 pg/ml). In the control group, leucocyte counts (10.700 +/- 3.600) and CRP-levels (1.2 +/- 1.1 mg/dl) showed minor pathologic results. TNF-levels were undetectable, too. While elevated TNF-levels measured quantitatively in patients with invasive bacterial infections, e.g. septicaemia due to Neisseria meningitidis, correlate well with prognosis of disease, in patients with cystic fibrosis such a relationship can't be found.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine
UniBasel Contributors:Heininger, Ulrich
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Enke
ISSN:0300-8630
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:06 Dec 2013 09:35
Deposited On:06 Dec 2013 09:35

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