Iridium-catalyzed asymmetric hydrogenation : development of New N,P ligands and hydrogenation of alkenyl boronic esters.
PhD Thesis, University of Basel,
Faculty of Science.
Official URL: http://edoc.unibas.ch/diss/DissB_10397
The aim of this thesis was the development of new N,P ligands for iridium-catalyzed asymmetric hydrogenations and evaluation of alkenyl boronic esters as substrates for this transformation. Initially, a concise synthetic route towards bicyclic pyridine-phosphinite ligand complexes was implemented. The middle section is mainly dedicated to structural modifications of the N,P ligand scaffold, in order to tune the activity and the selectivity. Those N,P ligand complexes were identified as a highly active and selective systems for the enantioselective hydrogenation of trisubstituted boronic esters. While on the other hand a member of the phosphinite-imidazoline ligand complexes provided the best results for the asymmetric reduction of terminal vinyl boronic esters. Finally the synthesis of those ligand complexes is described.
|Committee Members:||Togni, Antonio|
|Faculties and Departments:||05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)|
|Bibsysno:||Link to catalogue|
|Number of Pages:||311 S.|
|Last Modified:||30 Jun 2016 10:53|
|Deposited On:||26 Jun 2013 13:37|
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