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Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli

Hall, M. N. and Gabay, J. and Schwartz, M.. (1983) Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli. The EMBO Journal, 2 (1). pp. 15-19.

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Official URL: http://edoc.unibas.ch/dok/A5258211

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Abstract

We describe a lesion, lamB701-708, affecting the hydrophilic portion of the lambda receptor signal sequence. The C to A transversion of the sixth codon of the signal sequence changes a positively charged arginine to a neutral serine. The phenotype conferred by this alteration is unique among previously described signal sequence mutations. The results suggest an essential role for the charged amino acids of the hydrophilic segment in the initial interaction between a nascent secreted protein and a membrane export site. The results further suggest that synthesis of lambda receptor is coupled to its export.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0261-4189
e-ISSN:1460-2075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Nov 2017 08:34
Deposited On:22 Mar 2012 13:19

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