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Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection

Rosenlund, Helen and Bergström, Anna and Alm, Johan S. and Swartz, Jackie and Scheynius, Annika and van Hage, Marianne and Johansen, Kari and Brunekreef, Bert and von Mutius, Erika and Ege, Markus J. and Riedler, Josef and Braun-Fahrländer, Charlotte and Waser, Marco and Pershagen, Göran. (2009) Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Pediatrics : official publ. of the American Academy of Pediatrics, Vol. 123. S. 771-778.

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Official URL: http://edoc.unibas.ch/dok/A6006383

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Abstract

OBJECTIVE: Our aim was to investigate the role of measles vaccination and measles infection in the development of allergic disease and atopic sensitization. METHODS: A total of 14 893 children were included from the cross-sectional, multicenter Prevention of Allergy-Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle study, conducted in 5 European countries (Austria, Germany, the Netherlands, Sweden, and Switzerland). The children were between 5 and 13 years of age and represented farm children, Steiner-school children, and 2 reference groups. Children attending Steiner schools often have an anthroposophic (holistic) lifestyle in which some immunizations are avoided or postponed. Parental questionnaires provided information on exposure and lifestyle factors as well as symptoms and diagnoses in the children. A sample of the children was invited for additional tests, and 4049 children provided a blood sample for immunoglobulin E analyses. Only children with complete information on measles vaccination and infection were included in the analyses (84%). RESULTS: In the whole group of children, atopic sensitization was inversely associated with measles infection, and a similar tendency was seen for measles vaccination. To reduce risks of disease-related modification of exposure, children who reported symptoms of wheezing and/or eczema debuting during first year of life were excluded from some analyses. After this exclusion, inverse associations were observed between measles infection and "any allergic symptom" and "any diagnosis of allergy by a physician." However, no associations were found between measles vaccination and allergic disease. CONCLUSION: Our data suggest that measles infection may protect against allergic disease in children.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Braun-Fahrländer, Charlotte and Waser, Marco
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Charles C. Thomas Publ.
ISSN:0031-4005
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:40

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