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Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations

Ekelund, E. and Bradley, M. and Weidinger, S. and Jovanovic, D. L. and Johansson, C. and Lindgren, C. M. and Todorova, A. and Jakob, T. and Illig, T. and von Mutius E., and Braun-Fahrländer C., and Doekes, G. and Riedler, J. and Scheynius, A. and Pershagen, G. and Kockum, I. and Kere, J.. (2009) Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations. Acta dermato-venereologica, Vol. 89, H. 2. S. 115-121.

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Official URL: http://edoc.unibas.ch/dok/A5843250

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Abstract

Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Braun-Fahrländer, Charlotte
Item Type:Article, refereed
Bibsysno:Link to catalogue
ISSN:0001-5555
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:46
Deposited On:01 Feb 2013 08:40

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