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Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania

Armstrong Schellenberg J. R., and Shirima, K. and Maokola, W. and Manzi, F. and Mrisho, M. and Mushi, A. and Mshinda, H. and Alonso, P. and Tanner, M. and Schellenberg, D. M.. (2010) Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania. American Journal of Tropical Medicine and Hygiene, Vol. 82, H. 5. S. 772-781.

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Official URL: http://edoc.unibas.ch/dok/A5842843

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Abstract

Intermittent preventive treatment of malaria in infants (IPTi) with sulphadoxine-pyrimethamine shows evidence of efficacy in individually randomized, controlled trials. In a large-scale effectiveness study, IPTi was introduced in April 2005 by existing health staff through routine contacts in 12 randomly selected divisions out of 24 in 6 districts of rural southern Tanzania. Coverage and effects on malaria and anemia were estimated through a representative survey in 2006 with 600 children aged 2-11 months. Coverage of IPTi was 47-76% depending on the definition. Using an intention to treat analysis, parasitemia prevalence was 31% in intervention and 38% in comparison areas (P = 0.06). In a 'per protocol' analysis of children who had recently received IPTi, parasite prevalence was 22%, 19 percentage points lower than comparison children (P = 0.01). IPTi can be implemented on a large scale by existing health service staff, with a measurable population effect on malaria, within 1 year of launch
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Tanner, Marcel
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Williams and Wilkins
ISSN:0002-9637
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:56
Deposited On:08 Jun 2012 06:48

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