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Aminoglykoside bei Patienten mit Mukoviszidose und pulmonaler Exazerbation : Vergleich von Einmal- und Dreimalgabe

Heininger, U. and Böwing, B. and Stehr, K. and Solbach, W.. (1993) Aminoglykoside bei Patienten mit Mukoviszidose und pulmonaler Exazerbation : Vergleich von Einmal- und Dreimalgabe. Klinische Pädiatrie, Vol. 205, H. 1. S. 18-22.

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Official URL: http://edoc.unibas.ch/dok/A5839217

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Abstract

Twenty-six patients with cystic fibrosis and pulmonary exacerbations were enrolled in a prospective randomized study to compare the efficacy of aminoglycosides (tobramycin or netilmicin) administered once daily (21 episodes, 5 with netilmicin, 16 with tobramycin) and thrice daily (23 episodes, 2 with netilmicin, 21 with tobramycin), respectively. In addition, the patients received an anti-pseudomonal beta-lactam antibiotic. In the single-dose group the total daily dosage was 4.97 +/- 1.12 mg/kg (total dosage per exacerbation: 74.55 mg/kg), compared to 9.60 +/- 2.70 mg/kg in the triple-dose group (total dosage per exacerbation: 165.12 mg/kg). The mean peak and trough serum levels of the aminoglycoside were 8.31 +/- 1.76 mg/l and 0.18 +/- 0.10 mg/l, respectively in the single dose group compared to 6.12 +/- 1.30 mg/l and 0.58 +/- 0.31 mg/l in the triple dose group. Success of treatment, defined as decrease in leucocyte counts, normalization of elevated CRP-values, number of days in hospital and interval until next admission to hospital, was not different between both groups. We conclude that single daily dose of aminoglycosides was as efficacious as triple dose in our patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine
UniBasel Contributors:Heininger, Ulrich
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Enke
ISSN:0300-8630
Note:Note: Engl. Übersetzung des Titels: Aminoglycosides in patients with mucoviscidosis and pulmonary exacerbation. Comparison of once or three times daily administration -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:31
Deposited On:22 Mar 2012 14:19

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